A conserved heme redox and trafficking pathway for cofactor attachment
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چکیده
Thank you for submitting your manuscript for consideration by the EMBO Journal. I apologise for the delay in getting back to you with a decision but we have still not received the final report from the third referee despite several reminders and telephone calls. Since the other two reviewers seem to be in fair agreement, I would like to provide you with a preliminary decision on your manuscript, in order to save you from any unnecessary further loss of time. As you will see from the comments copied below, both reviewers find your study of the cytochrome C maturation pathway to be novel and interesting and support publication after a number of issues have been addressed which mainly are linked to the presentation of the manuscript.
منابع مشابه
A conserved haem redox and trafficking pathway for cofactor attachment.
A pathway for cytochrome c maturation (Ccm) in bacteria, archaea and eukaryotes (mitochondria) requires the genes encoding eight membrane proteins (CcmABCDEFGH). The CcmABCDE proteins are proposed to traffic haem to the cytochrome c synthetase (CcmF/H) for covalent attachment to cytochrome c by unknown mechanisms. For the first time, we purify pathway complexes with trapped haem to elucidate th...
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C-type cytochromes are distinguished by the covalent attachment of a heme cofactor, a modification that is typically required for its subsequent folding, stability, and function. Heme attachment takes place in the mitochondrial intermembrane space and, in most eukaryotes, is mediated by holocytochrome c synthase (HCCS). HCCS is the primary component of the eukaryotic cytochrome c biogenesis pat...
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Proper functioning of the mitochondrion requires the orchestrated assembly of respiratory complexes with their cofactors. Cytochrome c, an essential electron carrier in mitochondria and a critical component of the apoptotic pathway, contains a heme cofactor covalently attached to the protein at a conserved CXXCH motif. Although it has been known for more than two decades that heme attachment re...
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Post-translational maturation of c-type cytochromes involves covalent attachment of haem to the apocytochrome polypeptide by two thioether bonds. In bacteria, haem attachment occurs in the periplasm, after the separate translocation of haem and the polypeptide across the cytoplasmic membrane. In Escherichia coli, delivery and attachment of the cofactor requires eight or nine specific proteins, ...
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تاریخ انتشار 2009